What are the advantages/disadvantages to running a 10" vs 12" on the right rear .....and running an 8" vs 10" on the left rear????

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A lot of reasons, some are dictated by the rules of the organization, some have an overall max width, others have a tread width, plus you can change the circumference by changing wheel width, also the tire manufacturers have a recommended wheel width for a certain size tire, plus a lot is driver preference, and the feel they get with a wheel size, as it also changes the stiffness of the sidewall, plus the tread patch changes, so, there are several effects, it is hard to make a statement that covers everything. Bob!