Definitely a performance advantage
Single runners feeding fuel to each cylinder never has a lean or rich cylinder like a shared plenum of an intake manifold
There's no float bowl to slosh over, or run dry so you don't have to worry about the g forces in a turn upsetting fuel delivery
With that all said we ran a 305 that had carbs and FI, after initial excelleration the carbureted engines ran competitvly with the FI engines